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Field
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Targets in Amyotrophic Lateral Sclerosis Using Patient-Derived Models and Single-Cell Multiomic Data" Host Institution: University of Sheffield Primary Supervisor: Dr Richard Mead Secondary Supervisors
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(TIRF) microscopy, multiphoton microscopy, intravital microscopy, cleared tissue light sheet microscopy, single molecule localization microscopy, stimulated emissions depletion (STED) microscopy
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(Thorlabs) for imaging large cortical and subcortical areas in awake head-fixed animals, two 2-photon microscopes for single-cell electrophysiological experiments in brain slices (Chun et al, Science 2014
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of researchers lead key internationally competitive research from molecules to medicines, from patient to policy across a range of therapeutic areas. Prostate cancer shows significant clinical and genomic
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groups focus on studying the structure of proteins - in single molecules, but also in complex organisms. The MPIB is a leading international institute in the field of protein research. Scientists within
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neuroscience. For details on current research projects, see: http://www.ruhr-uni-bochum.de/igsn . The study programme includes a semester-wide neuroscience lecture "From Molecules to Cognition", oral and written
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of gut health) and/or in vitro fermentation models using faecal material to study fermentation capacity for different dietary fibres, gut microbiota composition and production of bioactive molecules
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radiation damage enhancement (e.g. yields of DNA strand breaks and their complexity) by radiosensitizing metal nanoparticles. Single-molecule experiments on DNA origami templates in the presence of metal
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cells Single-molecule dissection of ciliary membrane protein entry in C. elegans sensory neurons Structural and functional characterization of plectin inhibition in liver cancer Studying R-loop formation
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to determine why defects in intracellular transport cause neurodegenerative diseases. They use a combination of approaches including protein biochemistry and in vitro reconstitution, single-molecule biophysics