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sequencing output. This project brings together chemical biology, molecular biology, and computational science to achieve direct, single-molecule resolution of RNA cap structures. Job-ID: V000015123 Field
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or mapping single molecules within tissues for biomedical applications we want to hear from you. Join our interdisciplinary group as a postdoctoral researcher at Karolinska Institutet and help us transform
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(e.g. RNAi, CRISPR/Cas9, small-molecules). In this context, we also develop new computational tools for automated analysis and data visualization. These include algorithms and software applications
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the absence of antiretroviral therapy (ART). Using nonhuman primates as a preclinical model of HIV/AIDS, we have shown that a single dose of adeno-associated virus (AAV) vectors at birth can result in stable
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of researchers lead key internationally competitive research from molecules to medicines, from patient to policy across a range of therapeutic areas. Prostate cancer shows significant clinical and genomic
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for the cascade (building on initial discoveries in our group), (ii) apply one or more biophysical methods, such as microscale thermophoresis, ITC, fluorescence polarisation, single-molecule FRET, to characterise
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(Thorlabs) for imaging large cortical and subcortical areas in awake head-fixed animals, two 2-photon microscopes for single-cell electrophysiological experiments in brain slices (Chun et al, Science 2014
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approaches, to identify molecules that, after in vitro and in vivo validation, could be potentially used in future intelligent clinical trials. The clinical research focus is part of the National Centre
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. As part of the study, the candidate will receive training in single-molecule imaging. The applicant will also be expected to interact with graduate students in the laboratory and participate in
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phenotypes are used as readouts in drug screening approaches, to identify molecules that, after in vitro and in vivo validation, could be potentially used in future intelligent clinical trials. The clinical