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biochemistry (Protein expression and purification, and experience working with insect cell and yeast expression systems) and single-molecule biophysics. A deep interest in uncovering fundamental mechanisms
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enzymes/complexes. 6. Studies of ETFs containing modified flavins. 7. Kinetic characterizations. 8. Investigation of possible significance of buried disulfide bonds. 9. Fluorescence including single
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decide the fate of their RNAs - whether to translate, store, or degrade them. Using biochemical reconstitution, fluorescent labeling, and single-molecule imaging, you will explore how molecular machines
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. Our lab applies advanced structural and biophysical methodologies including cryo‑electron microscopy (cryo‑EM), X‑ray crystallography, single‑molecule fluorescence, and enzyme kinetics to elucidate how
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of splicing regulation using an array of state of the art biophysical, structural, molecular and chemical biology techniques, including single molecule analyses of splicing complexes as pioneered by
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cancer and neurodegenerative diseases. Duties and Responsibilities: Design and develop small molecules, nucleic acids and peptide therapeutics. Design, prepare and characterize nanoparticles. Employ state
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responsible for designing, building, and utilizing single-walled carbon nanotube field effect transistor (SWNT FET) sensors to probe biological phenomena at the single-molecule level. See Turvey et al. (2022
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with these molecules. A successful candidate will be familiar with the differentiation of iPSC to myeloid cells, assays evaluating viral kinetics including p24 AlphaLISA analysis and high content imaging
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Student or Postdoc (f/m/d) for the project Theory and Algorithms for Structure Determination from Single Molecule X‑Ray Scattering Images Project description Single molecule X‑ray scattering experiments
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, Recombinant protein expression and purification, biochemical and biophysical characterization of nucleic acids Computational model building and structure prediction Single-molecule fluorescence microscopy