-
Research Project Nucleic acids are potent triggers of immune responses. The presence of virus-derived RNA or DNA molecules activates nucleic acid sensors inside the host cell, which stimulates protective
-
data. We have developed in vivo single-cell CRISPR technologies to screen for dozens of molecular factors in vivo during developmental and disease. These technologies are a game-changer in the speed
-
, including liposome preparations and confocal microscopy. For structural work, single particle cryo-electron microscopy is extensively utilized at the Biological Electron Cryogenic Microscopy Center
-
spatial transcriptomics, genomics, or imaging-based methods. Experience with image analysis, single-cell or spatial omics data analysis. Familiarity with machine learning frameworks (e.g. PyTorch