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Field
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metals and inorganic materials are well-studied, little is known about systems where the host and dopants are small organic molecules (MoSS). There is huge potential of utilising MoSS for changing and
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the absence of antiretroviral therapy (ART). Using nonhuman primates as a preclinical model of HIV/AIDS, we have shown that a single dose of adeno-associated virus (AAV) vectors at birth can result in stable
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(e.g. RNAi, CRISPR/Cas9, small-molecules). In this context, we also develop new computational tools for automated analysis and data visualization. These include algorithms and software applications
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for the cascade (building on initial discoveries in our group), (ii) apply one or more biophysical methods, such as microscale thermophoresis, ITC, fluorescence polarisation, single-molecule FRET, to characterise
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of researchers lead key internationally competitive research from molecules to medicines, from patient to policy across a range of therapeutic areas. Prostate cancer shows significant clinical and genomic
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(Thorlabs) for imaging large cortical and subcortical areas in awake head-fixed animals, two 2-photon microscopes for single-cell electrophysiological experiments in brain slices (Chun et al, Science 2014
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approaches, to identify molecules that, after in vitro and in vivo validation, could be potentially used in future intelligent clinical trials. The clinical research focus is part of the National Centre
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phenotypes are used as readouts in drug screening approaches, to identify molecules that, after in vitro and in vivo validation, could be potentially used in future intelligent clinical trials. The clinical
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. As part of the study, the candidate will receive training in single-molecule imaging. The applicant will also be expected to interact with graduate students in the laboratory and participate in
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and cancer becoming an attractive drug target. The position is funded by an Emmy-Noether DFG grant and aims to combine single-molecule localization methods and cell biology to dechiper the stoichiometry