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host chromatin pathways (DFG Research Unit DEEP-DV, FOR5200). The group uses experimental infection systems, an array of high-throughput sequencing methods, and single-molecule live-cell imaging
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Max Planck Institute for Multidisciplinary Sciences | Gottingen, Niedersachsen | Germany | 7 days ago
, Dreier JE, Meisl G, Guido R, Knowles TPJ, Galvagnion C, Buell AK, Vendruscolo M, Michaels TCT. Global kinetic model of lipid-induced α-synuclein aggregation and its inhibition by small molecules. Proc Natl
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Max Planck Institute for Multidisciplinary Sciences | Gottingen, Niedersachsen | Germany | 7 days ago
, 28943-54 (2025) DOI : 10.1021/jacs.5c06971 The small molecule inhibitor anle145c thermodynamically traps human islet amyloid peptide in the form of non-cytotoxic oligomers, S. Manikam, S. Ryazanov, A
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PhD Student (f/m/d) | NMR structure of AP-L complex of hIAPP and its effect on fibrils and membranes
Max Planck Institute for Multidisciplinary Sciences, Göttingen | Gottingen, Niedersachsen | Germany | 3 days ago, V. Singh Mithu, K. Giller, E. Nimerovsky, K. Overkamp, L.B. Andreas, S. Becker, C. GriesingerJACS 147, 28943-54 (2025) DOI : 10.1021/jacs.5c06971 The small molecule inhibitor anle145c
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these, Nucleotide-binding, Leucine-rich-Repeat proteins (NLRs) constitute a large family of intracellular receptors of pathogen-associated molecules, termed effectors. To restrict infection, NLRs trigger a response
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Max Planck Institute for Multidisciplinary Sciences, Göttingen | Gottingen, Niedersachsen | Germany | 4 days ago
model of lipid-induced α-synuclein aggregation and its inhibition by small molecules. Proc Natl Acad Sci U S A. 2025 Jul;122(26):e2422427122. doi: https://doi.org/10.1073/pnas.2422427122 Dreier JE
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. Our research combines computational chemistry, cheminformatics, bioinformatic and AI to design new molecules and enzymes for unprecedented catalytic functions. In this project, you will: Develop
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to counteract the SARS-CoV-2 pandemic it has become increasingly clear that RNA is on the verge of becoming another major molecule class for the fields of diagnostics, prevention and treatment of diseases. Funded
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the verge of becoming another major molecule class for the fields of diagnostics, prevention and treatment of diseases. Funded by the Elite Network of Bavaria (ENB), the graduate programme RNAmed takes a
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groups focus on studying the structure of proteins - in single molecules, but also in complex organisms. The MPIB is a leading international institute in the field of protein research. Scientists within