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. Investigating epigenetic regulation (DNA methylation, histone modifications) in stem cell fate decisions, reprogramming, and disease modeling using AI predictive tools. Combining computational virtual cell
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proficient in epigenome-related techniques (DNA methylation and/or histone modifications) and their analysis. Alternatively, the candidate comes with an expertise in CRISPR-based epigenetic editing
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, epigenomics, and proteomics) to simulate virtual neural stem cells or organoids. Investigating epigenetic regulation (DNA methylation, histone modifications) in stem cell fate decisions, reprogramming, and
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comfortable with Unix/Linux systems and high-performance computing clusters. Experience in epigenomic data analysis, especially DNA methylation sequencing, is preferred, along with knowledge of workflow
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, optimizing, and validating procedures for RNA expression analyses; Introducing methods from the field of epigenetics (e.g., DNA methylation); Participating in research investigating: exposure levels
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scalable approaches to early cancer detection and risk stratification, with particular emphasis on DNA methylation dynamics and circulating tumour DNA (ctDNA) in liquid biopsies. Our work sits at
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the role of the Ku70 C-terminal domain and its methylation in DNA damage response, along with the regulatory functions of lysine methyltransferase SETD4. Additionally, the lab aims to uncover new mechanisms
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interest) in nanopore based DNA methylation analysis and previous bioinformatics training. Requirements: PhD in a STEM subject. Candidates with degrees in neuroscience, data science, bioinformatics, and
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://www.nottingham.ac.uk/research/groups/cells-organisms-and-molecular-genetics/people/index.aspx ). The role will primarily involve conducting bioinformatic analyses of existing RNA-sequencing and whole-genome DNA
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techniques: handling biological samples, extracting nucleic acids from blood and tumors, PCR, Sanger sequencing, mass sequencing (NGS panels), DNA methylation analysis (EPIC array), and results analysis (0