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Field
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deregulations involved in the development and progression of human lymphomas. The successful candidate will contribute to a research program aimed at generating, interpreting, and developing in vivo CRISPR Cas9
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human health. Within this mission, the Iorio Group works at the intersection of computational biology, functional genomics, and precision oncology, integrating machine learning, large-scale CRISPR
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proficient in epigenome-related techniques (DNA methylation and/or histone modifications) and their analysis. Alternatively, the candidate comes with an expertise in CRISPR-based epigenetic editing
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will apply include endogenous protein tagging by CRISPR and integrases, in-cell interaction proteomics by proximity labeling, subcellular localization by spatial proteomics and fluorescence microscopy
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chromatin accessibility, CRISPR based gene and epigenetic perturbation, and deeply phenotype human cohorts to define causal mechanisms driving post infectious and post tuberculosis lung disease. Postdoctoral
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interests, you will have the opportunity to work with: High‑throughput functional genomics: pooled CRISPR and base‑editing screens, barcoded overexpression libraries, massively parallel reporter assays
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of São Paulo (UNIFESP), in Brazil, aims to investigate how CRISPR-Cas9-mediated genetic modification of Invariant Natural Killer T (iNKT) cells can modulate their antitumor activity and therapeutic
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homeostasis. The Wang group has been using Cre-loxP/Flp-frt and CRISPR strategy to manipulate genes of interest and use chemogenetics/optogenetics strategy to manipulate neuronal activities in specific neuron
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-targeting CRISPR systems (Zolboot et al. in preparation), and single-cell, isoform-sensitive measurements of translation in vivo (Ribo-STAMP; Sison et al. Nature 2026). Using these tools, we have identified
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research, CRISPR technologies, novel humanized mouse models of neuromuscular disorders and state-of-the-art delivery technologies for nucleic acid therapeutics, as well as research on disease mechanisms (see