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-impact publications, tackling methodology for synthetic patient alignment and iterative self-improvement for robust generalization, explainability, and uncertainty assessment. Where appropriate, outcomes
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scalable synthesis of entire genomes with precision. Second, we must understand what to write - determining which DNA sequences will generate biological systems that perform the desired functions. Addressing
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characterizing patient-derived microglia-integrated nigrostriatal assembloids to investigate neuroinflammation in the pathogenesis of Multiple System Atrophy (MSA) and to evaluate therapeutic modulation
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which DNA sequences will create biological systems that perform desired functions. Solving these challenges will unlock the potential of biology for transformative solutions in health, sustainability