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entomology and plant pathology research Research methodologies used in studying vector-endosymbiont-pathogen-host plant interactions Molecular biology techniques including genomics, transcriptomics, nucleic
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Center for Biologics Evaluation and Research (CBER) | Silver Spring, Maryland | United States | 12 days ago
focuses on improving the safety of gene therapy products, including AAV vectors, through mechanistic and translational laboratory studies. The fellow will assess quality attributes (CQAs) that may influence
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to vaccine development utilizing viral vectors to contribute to an effort in developing neoantigen expressing vaccines for clinical investigations. The position is available as part of a multi-disciplinary
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analyze DNA and RNA sequences of selected Brassica pathogens Predict effectors, and clone them in expression vectors Develop and perform effectoromics screens in Brassica cultivars and wild germplasm
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Responsibilities: Develop and optimize strategies for multiplex CRISPR-Cas genome editing in Brassica Design, construct, and validate CRISPR-Cas vectors for efficient gene editing Generate edited Brassica plants
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through the collaborative development, production, and characterization of AAV vectors for experimental applications. The successful candidate will work as an integral member of a team focused on designing
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leverage them to build gene therapy vectors and regulatory-element directed expression systems toward the long-term goal of proximal digit and limb regeneration. Additional projects explore gene therapy
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, transfection, mammalian gene and protein expression analysis, and virus production and propagation. Expertise in project relevant areas, such as HIV replication, vector construction and modification, aptamer
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Center for Biologics Evaluation and Research (CBER) | Silver Spring, Maryland | United States | 13 days ago
an understanding of the molecular mechanisms underlying neuromuscular and neurological diseases; Gain expertise in the design and production of AAV vectors for delivering therapeutic genes in preclinical disease
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Research Associate, Translational Research Fellow - Dept. Ophthalmology Visual & Anatomical Sciences
. Laboratory techniques such as cell culture, PCR/qPCR, Western blotting, cryosectioning, tissue staining, and immunohistochemistry are required. Prior experience in rabbit or rodent models, AAV vector design