PhD position in systems biology (Zampieri Lab)

University of Basel, Switzerland

Updated: 2 months ago

Your position

The candidate will have the opportunity to exploit some of the cutting-edge experimental and computational methods, comprising constraint-based and kinetic modeling, statistical analysis of large datasets, high-throughput metabolomics, time-lapse microscopy, to investigate how to pharmacologically interfere with fundamental mechanisms in the regulation of cancer metabolism. Available resources at the department include a mouse facility, high-end FACS, IT and microscopy facilities, the Life Sciences Training Facility (for gene expression and proteome profiling) and much more.

The candidate is expected to have a strong background and interest in quantitative disciplines, excellent teamwork and communication skills in English. The candidate will have the opportunity to develop the following project with a lot of academic freedom and strong support from senior members in the lab, and at the same time to play an active role in shaping and creating inspiring research and working environment.

In line with our and Uni Basel values (

https://www.unibas.ch/en/Research/Values-Ethics/Diversity-and-Inclusion.html

), we are committed to sustain and promote an inclusive culture, ensure equal opportunities and value diversity and respect in our working and learning environment.

We are looking for a highly motivated doctoral researcher to develop new metabolomics strategy to advance and speed up anti-cancer drug discovery.

Your main tasks will be:

  • Developing new strategies to combine high-throughput metabolomics with 3D cell culture models
  • Perform large chemical and genetic studies in cancer cell lines derived spheroids
  • Develop predictive model of drug response by comparing 2D to 3D cellular systems
  • Testing and validating the relevance of such models in patient tumour specimens
  • Support and preparation of scientific reports and journal articles



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