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destabilized in human disease using advanced iPSC-derived skin organoid models of hidradenitis suppurativa. This project integrates genetic, inflammatory, and metabolic perturbations to uncover mechanisms
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on the replacement and/or regeneration of dysfunctional human cells, tissues or organs to restore or establish physiological functions. Thematic priorities are translational regenerative technologies, cell-based
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of gene dosage in regulating cellular function in male and female animals - from individual genes to chromosome-wide scales. We combine work in non-model organisms (like mosquitos or brine shrimp) with
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to engineer human cells using synthetic gene circuits and biosensing platforms, develop novel biosensing systems for real-time monitoring of cellular states, create genetic architectures for precise therapeutic
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collaborative interdisciplinary team that uses population genomics to support the development an implementation of working experimental transposon models in the lab. Project background Horizontal gene transfer
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cutting-edge technologies to dissect these interactions: high-density microelectrode arrays (HD-MEAs) for large-scale electrophysiology, spatial transcriptomic methods, and human iPSC-derived neuronal