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regionalization and lamination of the human cortex and their deregulation in disease using different in vitro models derived from human pluripotent stem cells. The successful candidate will be in charge of
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; Jacob et al., Cell Stem Cell 2022; Di Carlo et al., Nature Immunology 2023). Building on these findings, we aim at identifying novel mechanisms regulating the tumor microenvironment and antitumor immunity
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demonstrated that this transition involves mechanochemical dynamics in gastruloids, in vitro models derived from embryonic stem cells (Hashmi et al., eLife 2022; Gsell & Tlili et al., Nature Physics 2025
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and α-synuclein pathology. The research combines advanced 3D stem cell modeling, neuroimmune interaction studies, high-content imaging, molecular and biochemical analyses and the evaluation
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objective of the project. Experimental Systems and Approaches: Cultured human cell lines and mouse embryonic stem cells. The project involves the development and application of innovative genomic approaches
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Fondation Rothschild (HFAR), directed by Prof. Eric Gabison (HFAR / University Paris Cité / INSERM U1342, Institut de Recherche Saint-Louis (IRSL), « Stem Cells Biotechnologies » team). The team is composed
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stem cell biology, stress granule biology, multi-omics, and therapeutic target validation. Key responsibilities: Generation, maintenance, and differentiation of human iPSCs into midbrain organoids
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stem cell (iPSC)-derived neuronal models to elucidate the molecular and cellular alterations contributing to neurodegeneration in familial and idiopathic forms of PD, Dementia with Lewy bodies (DLB
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expertise in macrophage/stroma interactions. Applicants must hold a PhD (or be close to completion: thesis submitted at the time of application) in immunology, stem cell biology, or stromal cell biology
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also have conceptual, empirical, or ethical consequences. Given the ubiquitous role of lineages in biology (central to development, regeneration, stem cell biology, cancer biology, and more), a clearer