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pioneering method for obtaining the full conformational landscapes of biomolecular complexes at atomic scale from cryo electron microscopy (cryo-EM) images. It has been shown that MDSPACE analyzes
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is located in Montpellier, a vibrant research hub on the Mediterranean coast, and hosts world-class expertise in advanced microscopy, including multiplexed imaging, single-molecule super-resolution
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, rheological properties of gels) and printing conditions (laser power, printing time). Characterization via SEM/EDX, TGA, SEC-MALS, fluorescence microscopy, XRD, and SAXS. - Cytotoxicity studies of HepG2 cells
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. This project aims to obtain high-resolution structures of the T4SS pilus by cryo-electron microscopy (cryo-EM), with a clear objective of rapidly generating structural data suitable for publication
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for the position. The interested candidate should have a PhD with scientific training in chemistry or materials science. Expertise in one or several of the following skills are considered assets: confocal microscopy
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to develop a new generation of fluorescence microscopy methods aimed at overcoming current limitations in acquisition time for single-molecule imaging. The project explores original strategies for temporal
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responses, α-synuclein pathology Immunofluorescence and confocal microscopy, high-content imaging, quantitative image analysis, SDS-PAGE and Western blot Testing of candidate compounds Contribution to single
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lifetime microscopy and single-molecule localization microscopy, with the aim of enabling dynamic observation of living biological systems and nanostructures. This research lies at the interface of physics
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Eligibility criteria - The successful candidate must hold a PhD in biology and have experience in molecular and cellular biology, cell culture, and microscopy. - Scientific knowledge, scientific rigor
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/Qualifications Hold a PhD in Biology, Biochemistry, or a related field; Have a strong background in molecular and cellular biology techniques; Ideally possess experience with mouse models, mammalian cell culture