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molecular networks of drug resistance and pathogenicity. We have access to state-of-the-art robotic platforms for profiling bacterial physiology, and core-facilities for next-generation sequencing and
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Job Description Project Description: Drug toxicity and resistance are the leading causes of therapeutic failures. The Chen Lab (https://www.stjude.org/research/labs/chen-lab-taosheng.html) studies
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of steroid metabolism that lead to resistance to hormonal therapy. Our work is revealing fundamental endocrine mechanisms in both normal physiology and disease, including stress, aging, and glucocorticoid
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, cytokines, and chemokines. Assess epithelial barrier integrity and function using transepithelial electrical resistance (TEER), permeability assays (e.g., FITC–dextran), and tight-junction analyses. Evaluate
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already adapt and resist, and what barriers hinder their ability to fully exercise their agency. Our findings will inform policies that can strengthen these local adaptation strategies and ensure that IPLC
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human health. The lack of discovery of new modes of action, increasing costs of registrations, and development of resistance among weeds and pests, further limit the prospects for relying on chemical
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of resistance among weeds and pests, further limit the prospects for relying on chemical pesticides for crop protection. There is an urgent need to assess the consequences for arable crop production given
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resistance and the development of new cancer therapeutics that include immunotherapeutics. The particular areas of emphasis for this position center on studies of resistance to current therapeutics deployed
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United States. Assessment of different varieties of cane for yield and quality traits (e.g. cold tolerance, recoverable sucrose, biomass yield, disease resistance, etc.) will be conducted as part of this project
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in hand by the start of the appointment. Experience with bacterial cultures and aseptic technique. Experience with molecular approaches to study bacterial survival and antibiotic resistance. Preferred