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About the project Systemic amyloidosis comprises severe protein misfolding diseases in which amyloid fibrils accumulate across multiple organs, leading to progressive dysfunction. AL (light‑chain
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for therapeutic intervention. Initially focused on tools to study human protein complexes, the lab has expanded to novel screening platforms in human cells for applications such as Deep Mutational Scanning and
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-based evolutionary simulations to study the evolution of transcriptional systems after WGD. We will in particular study whether and under which circumstances polyploids exhibit a short-term adaptive
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