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repeat leads to RNA gain-of-function toxicity by creating long, abnormally folded transcripts from the mutant DMPK allele that engage in the formation of abnormal RNA-protein aggregates, visible as nuclear
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morphogenetic proteins (BMPs). Compared to protein-based approaches, mRNA therapy enables transient, tunable, and safe expression of regenerative signals exactly where and when they are needed. In this role you
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Programme? Not funded by a EU programme Is the Job related to staff position within a Research Infrastructure? No Offer Description Do you want to contribute to the protein transition? Are you interested in
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of micropollutants from waste water and drinking water, but also the removal of protein bound toxins in kidney dialysis. The project is part of a larger NWO-VICI project, and as such the recruited PhD student will be
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build upon the existing Alpha framework (originally developed to model protein quality, see https://alpha-tool.eu ) and further develop it as a research-oriented modelling and demonstration platform
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Salerno investigates how molecular mechanisms govern the behaviour of immune cells. More specifically, she studies which mechanisms are active between RNA and proteins and how they can be manipulated
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, 2025). The precise proteins and mechanisms that control transcriptional integrity upon persisting DNA damage are poorly understood. In this project, we will use forward genetic screens in the model
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) to evaluate protein synthesis. In addition, you will be involved in other ongoing projects in the lab. For one of them, we are developing innovative therapeutic approaches for CMT, following up on our published
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has also elucidated the organisation, expression and functions of the viral proteins of HCV. Moreover, Charles Rice produced the first infectious molecular clone of HCV, with which he demonstrated