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Max Planck Institute of Molecular Cell Biology and Genetics, Dresden | Dresden, Sachsen | Germany | about 1 month ago
) in Proteomics. The Toth-Petroczy lab is an interdisciplinary research group at MPI-CBG and CSBD that studies protein evolution. As a group of scientists with diverse backgrounds in computer science
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analysis pipeline to probe cell and tissue mechanics and cell–cell mechanical interactions. Microfluidic systems for controlled migration assays, immune‑cell trafficking, and spatially resolved tumor–immune
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inputs to reshape the proteome and metabolome in ways that influence health and disease. We use a multidisciplinary approach that integrates cellular and molecular biology, protein–metabolite interaction
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biochemistry. Expertise in e.g. CRISPR-mediated gene editing, protein structure prediction, mass spectrometry-based proteomics, or fluorescence microscopy. Expertise and interest in functional analysis
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inputs to reshape the proteome and metabolome in ways that influence health and disease. We use a multidisciplinary approach that integrates cellular and molecular biology, protein–metabolite interaction
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learning, transfer learning, and data fusion techniques to integrate heterogeneous omics datasets and clinical metadata. Conduct network-based analysis (gene regulatory networks, protein-protein interaction
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complexes Protein lipid interactions and membrane reconstitution using nanodiscs, liposomes, monolayers, or related systems Structure function analysis by X-ray crystallography, biochemistry, and biophysics
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direction and publication. Research activities may include AI-assisted target discovery and biologic design, protein engineering and developability optimization, mechanistic studies in metabolic disease
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About the project Systemic amyloidosis comprises severe protein misfolding diseases in which amyloid fibrils accumulate across multiple organs, leading to progressive dysfunction. AL (light‑chain
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circuits operate and adapt. Recent work from us and others revealed that the structure and function of synapses is not only determined by the number, but also the nanoscale organization of synaptic proteins