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William Dunn School of Pathology. The project will involve the mechanistic dissection of protein quality control pathways using quantitative cell-based assays, flow cytometry-based and imaging approaches
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filtration). Analyzing and characterizing purified proteins using SDS-PAGE, Western blot, ELISA, UV spectroscopy, BCA/Bradford assays, etc. Actively contributing to critical data analysis, protocol
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and supportive research group led by Prof. Pedro Carvalho at the Sir William Dunn School of Pathology. The project will involve the mechanistic dissection of protein quality control pathways using
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% Experimental Design and Implementation: Design and perform experiments to assess the regulatory roles of histone PTM-interacting proteins in transcription and associated processes. Develop and optimize genomic
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experience is desirable Essential skills: Strong expertise in microbiological techniques Proven experience in the purification and analysis of protein complexes Experience in structural biology, ideally in
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generation, sequence analysis, and data management Rapid Evaluation of newly emerging computational tools relevant for protein design Implementation and optimization of experimental workflows for rapid protein
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mammalian cell culture. Experience with expression (E. coli, yeast, and mammalian cells) and purification of proteins. Experience with Drosophila Genetics, Dissection, Immunostaining and Confocal Microscopy
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and biophysics. Develop computational pipelines integrating ASR, structure prediction, and energetic analysis. Apply and/or develop ML/AI methods for protein design and evolutionary inference. Analyze
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crystallography and natural product research is required. Knowledge in enzymology, protein design, molecular biology, microbial metabolism, natural product analysis (LCMS, NMR etc.) and/or bioinformatics
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culture. Experience with expression (E. coli, yeast, and mammalian cells) and purification of proteins. Experience with Drosophila Genetics, Dissection, Immunostaining and Confocal Microscopy. Brief