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limited understanding of sperm molecular biology. In this PhD project, you will investigate how molecular assemblies in human sperm are organized in situ and how this architecture relates to fertility and
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into this type of research: actual nerve biopsies from patients with Charcot-Marie-Tooth neuropathy due to YARS1 mutations, along with matching iPSC-derived motor neurons and Drosophila models. Now, we
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. These coordinated hormonal activities influence not only the rate of cell division but also the duration and dynamics of each phase of the cell cycle. With the advent of advanced technologies, such as single-cell
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signalling pathways are critical for driving cell cycle progression. These coordinated hormonal activities influence not only the rate of cell division but also the duration and dynamics of each phase
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and Saeys teams. In this research project you will develop and apply algorithms to link clinical phenotypes of metastasis to molecular phenotypes in mouse models. It is known that metastases exhibit
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. Our mission is to move beyond descriptive biology and develop predictive, mechanistic models that connect molecular regulation to cellular and systems-level phenotypes. The Laboratory of Computational
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Saelens team. Research Project In this research project you will develop probabilistic deep-learning models that automatically extract biological and statistical knowledge from in vivo perturbational omics
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we resolved their structures (Ying et al., 2024, Science; Wei et al., 2025, Plant Communications; Hu et al., 2025, Trends Biochem. Sci.). With this PhD project, we aim to unravel the molecular bases
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the development of genetic autoinflammatory diseases. Using techniques in cell biology, molecular biology and biophysics you will investigate how loss of function of the RNA editing enzyme ADAR1 causes the human