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how genetic and environmental factors interactions shape mucosal immunity and metabolism. Our approach includes state-of-the-art multi-omics, novel organoid culture, genetically engineered murine models
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models of sporadic low-grade glioma and Neurofibromatosis Type 1 (NF1)-related optic pathway glioma to accomplish these goals. We are additionally interested in how environmental exposures affect the non
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therapies, and disease models, including mutant mice and iPSC-derived neurons to further understand neurodegenerative processes. These projects are funded by multiple grants from the NIH. This opportunity
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infection. We focus on defining host pathways that can be therapeutically leveraged to target the HIV reservoir. Our work integrates molecular virology, primary human cell systems, and in vivo models. We
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researchers, to translate findings across model systems and human cohorts. Mentor junior lab members, including graduate students and research staff, and contribute to fostering a supportive and rigorous
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), Parkinson's disease and other forms of neurodegeneration. We are particularly interested in synaptic injury. We work with animal models (mostly mice) and with patients in the hospital, and collaborate with
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model, etc.). Additionally, the researcher will develop innovative chemical tools and probes to interrogate fundamental biologic processes and mechanism of action. In addition to high-quality research
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, metabolomic and genomic approaches, including on the single cell level, to understand how metabolites influence chromatin and gene expression in the brain. Further, we apply mouse behavioral models and in vitro
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/i/a screening, single-cell multiomics, tissue engineering, and animal models. Our current research primarily focuses on four key areas: 1) Developing robust, chemically defined differentiation
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/splicing, as well as the development of enhancer activity lineage-tracing approaches in stem cell and/or mouse models. We are particularly interested in candidates with expertise in transcriptional