Senior Bioinformaticist

University of Texas at Arlington, United States

Updated: 3 months ago
Location: Arlington, TEXAS
Deadline: ;

Position Information


Posting Number S06514P
Position Title Senior Bioinformaticist
Department Health Innovation Institute
Location Arlington
Position Status Full-time
Work Schedule
Monday-Friday; 8:00am-5:00pm
  • Based at UTA (Arlington, TX) with regular on-site collaboration with Cook Children’s teams in Fort Worth.
Salary Salary is commensurate with qualifications and relevant experience.
Pay Basis Monthly
Job Summary
The Senior Bioinformaticist will lead the development and strategic implementation of advanced bioinformatics solutions within the joint UTA–Cook Children’s precision medicine and genomic research ecosystem. This position will develop the strategy, manage pipeline architecture, and drive innovation in genomic data integration. The candidate will serve as a senior architect bridging population genetics, clinical variant interpretation, and translational neuroscience within precision neurology programs. The position will work within UTA’s Center for Innovation in Health Informatics (CIHI) and collaborate closely with Cook Children’s variant scientists, genetic counselors, clinicians, data scientists, and computational teams.
Essential Duties and Responsibilities
Pipeline Architecture and Optimization
  • Design and oversee enterprise-scale genomic pipelines for SNV/indel calling, structural variant analysis, annotation, and QC.
  • Implement cloud- and HPC-based workflows for large-scale genomic datasets.
  • Establish best practices for data governance, security, IRB, and PHI protection standards across clinical and research environments.
  • Lead design and maintenance of end-to-end germline and somatic WES/WGS pipelines, including rare variants, CNV, mosaicism, and gene-based burden analyses.
  • Optimize pipelines for consortium-scale studies (>100k) using HPC and cloud environments.


Strategic Variant Interpretation Leadership
  • Lead innovative approaches for complex gene-specific variant curation, integrating multiple annotation resources (gnomAD, ClinVar, HGMD, UniProt).
  • Serve as subject matter expert for the Cook–UTA variant review boards, providing expert level variant summaries and pathogenicity assessments.
  • Lead development ACMG/AMP-aligned re-analysis pipelines.

Data Integration & Knowledgebase Strategy
  • Architect for scalable, harmonized, searchable structures that integrate genomic, clinical, and experimental/functional datasets.
  • Drive development of UTA–Cook knowledgebases and web-facing tools that support clinical genetics and translational research for precision medicine programs.

Advanced Analytics and Machine Learning
  • Lead ML/AI approaches for pathogenicity prediction, phenotype clustering, or multimodal data modeling.
  • Publish findings and contribute to grant proposals, translational informatics studies in precision neurology, and peer reviewed manuscripts.

Software Development and Visualization
  • Oversee creation of R/Shiny, Python, or JavaScript-based applications for interactive variant exploration or phenotype dashboards.
  • Ensure usability and scalability of visualizations for clinical teams, publications, and presentations.

Clinical Informatics & Decision Support Leadership
  • Partner with Cook IT, Epic analysts, and UTA computational teams to operationalize unstructured data into structured formats using ontologies and NLP-based approaches.
  • Guide clinical decision-support tool development for precision neurology and rare disease programs.

Mentorship and Program Development
  • Represent UTA-Cook partnership in strategic planning and external collaborations as well as with variant scientists, genetic counselors, bioinformaticians, researchers, and clinical partners.
  • Mentor students and junior staff; Collaborate with Lead Faculty to develop training programs in Genome-Informed Care.
  • Other Duties as Assigned
Minimum Qualifications
  • Master’s degree in Bioinformatics, Computational Biology, Genetics, Data Science, Computer Science, or related field.
  • Five (5) years of experience in genomic data processing, variant annotation, or large-scale data analysis.
  • Proven leadership in pipeline development, variant interpretation, and clinical informatics.
Preferred Qualifications
  • PhD in Bioinformatics, Genetics, Computational Biology, or a related quantitative field.
  • Demonstrated success in integrating large multimodal datasets (genomic, phenotypic, functional).
  • Experience leading VCF/FASTQ processing, variant interpretation frameworks, and cloud-based deployments.
  • Experience leading clinical genetics programs or variant scientists.
  • Experience leading with machine learning, predictive modeling, or structure-informed variant analysis.
  • Track record of high-impact publications and active participation in international consortia.
Knowledge, Skills and Abilities
  • Expert in of genomic annotation tools (VEP, ANNOVAR, bcftools, bedtools).
  • Expertise with ACMG/AMP guidelines, variant curation frameworks, and ClinVar submission standards.
  • Deep expertise in statistical genetics methods (GWAS, PRS, CNV, linkage, meta- analysis) and analysis of rare and common genetic disorders.
  • String command of using public biomedical resources (gnomAD, ClinVar, UniProt, UCSC Genome Browser).
  • Demonstrated experience with R/Shiny or web-based tools for research dashboards.
  • Expert understanding of ontologies (HPO, MONDO) and clinical data structures.
  • Excellent communication skills: ability to support cross-disciplinary teams spanning AI, clinical neurology, genetics, and IT.
  • Ability to manage multiple projects in a high-velocity, collaborative research environment.
Other Requirements
Workplace and Eligibility Conditions
  • Will engage with secure computing environments, IRB-protected datasets, and sensitive clinical data workflows.
  • Office, computational, and occasional clinical–research interface settings.
Benefits Eligible Yes
Benefits at UTA
We are proud to offer a comprehensive benefits package to all our employees at the University.
https://www.uta.edu/hr/employee-benefits
To help you understand the full value of these benefits, we have created a tool that calculates the total worth of your compensation package. This tool takes into account all of the benefits that you are eligible for, including health insurance, retirement plans, and paid time off. To access this tool and learn more about the total value of your benefits, please click on the following link:
https://resources.uta.edu/hr/services/records/compensation-tools.php
CBC Requirement
It is the policy of The University of Texas at Arlington to conduct a criminal background check on any applicant who is under final consideration for employment with the University.
This position may have access to critical infrastructure as defined by Section 113.001(2) of the Texas Business and Commerce Code. If so, to be hired for and continue to be employed in this position you must maintain the security or integrity of the infrastructure as set forth in Texas Executive Order GA-48. By assuming this position, and if you have access to critical infrastructure, you authorize the University to conduct routine background checks.
EEO Statement
It is the policy of The University of Texas at Arlington (UTA or The University) to provide an educational and working environment that provides equal opportunity to all members of the University community. In accordance with federal and state law, the University prohibits unlawful discrimination, including harassment, on the basis of race, color, national origin, religion, age, sex, sexual orientation, pregnancy, disability, genetic information, and/or veteran status. The University also prohibits discrimination on the basis of gender identity, and gender expression. Retaliation against persons who oppose a discriminatory practice, file a charge of discrimination, or testify for, assist in, or participate in an investigative proceeding relating to discrimination is prohibited. Constitutionally-protected expression will not be considered discrimination or harassment under this policy. It is the responsibility of all departments, employees, and students to ensure the University’s compliance with this policy.
University Information
The University of Texas at Arlington (UTA) is located in the heart of the Dallas-Fort Worth-Arlington metroplex, a vibrant and diverse metropolitan area that is home to over 7 million people, one of the fastest-growing tech economies in the United States, and a wide array of arts, entertainment, and cultural activities. As a comprehensive teaching, research, and public service institution, UTA is dedicated to the advancement of knowledge through scholarship and creative work. With an enrollment of more than 42,000 students, UTA is the second largest in the University of Texas System. As a result of its combination of rigorous academics and innovative research, UTA is designated as a Carnegie R-1 “Very High Research Activity” institution and nationally recognized for its commitment to student success and service. It ranks No. 5 in Military Times’ “Best for Vets: Colleges” and is the top university in North Texas for its graduates’ salaries (The Wall Street Journal). UTA is designated as both a Hispanic-Serving Institution and an Asian American and Native American Pacific Islander-Serving Institution and is No. 6 for undergraduate ethnic diversity in the United States (U.S. News & World Report, 2023). With a global alumni network of approximately 280,000 – including leaders at many of the 24 Fortune 500 companies headquartered in North Texas – UTA contributes an estimated $29 billion annually to the Texas economy.
UTA is expanding its regional footprint by building a regional campus, called UTA West, in Parker County on the far west side of Fort Worth. It is scheduled to open in fall 2028. This initiative aligns with the university’s strategic growth and commitment to serving the broader community. Furthermore, UTA has launched the RISE 100 initiative, aiming to recruit 100 new tenure-system faculty to strengthen its research enterprise and leadership in key academic areas. Learn more at https://www.uta.edu/administration/president/strategic-plan/rise100 .
This is an exciting time to join UTA and contribute to its bold vision for the future.
ADA Accommodations
The University of Texas at Arlington is committed to providing reasonable accommodation to individuals with disabilities. If you require reasonable accommodation in completing this application, interviewing or otherwise participating in the employee selection process, please direct your inquiries to 817-272-5554 or email ADADocs@uta.edu .


Posting Detail Information


Number of Vacancies 1
Open Until Filled
Minimum Number of References Required 3
Maximum Number of References Accepted 3
Special Instructions to Applicants
Applicants must include in their online resume the following information: 1) Employment history: name of company, period employed (from month/year to month/year), job title, summary of job duties and 2) Education: school name, degree type, and major.

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