Research Associate/Fellow (Fixed term)

This role will provide support to an ongoing MRC project grant characterising the molecular pharmacology of the P2Y2 receptor (P2Y2 R).  The P2Y2 R is a Class A GPCR physiologically activated by the nucleotides UTP and ATP. Subsequent Gq mediated signalling ultimately drives inflammation, wound healing and cell migration. Aberrant P2Y2 R mediated signalling has been implicated in pathological inflammation and fibrosis in progressive diseases such as idiopathic pulmonary fibrosis (IPF) and cancer growth and metastasis. Therapeutic strategies aimed at modulating P2Y2 R activity would therefore have considerable utility as anti-inflammatory or anti-fibrotic treatments. However, drug discovery programmes targeting P2Y2 R have had limited success due to the low affinity and/or poor bioavailability of compounds which has been further exacerbated by a lack of detailed P2Y2 R specific structural information and pharmacological characterisation.  

We have recently developed novel selective fluorescent antagonists for scientific investigation of the P2Y2 R (Conroy et al., 2018 (https://doi.org/10.1021/acs.jmedchem.8b00139 ); Knight et al., 2024 (https://doi.org/10.1021/acsmedchemlett.4c00211) ). The role holder will use these novel fluorescent antagonists alongside bioluminescence resonance energy transfer (BRET), confocal imaging and downstream functional assays (calcium mediated signalling assays, G protein recruitment assays) to quantify the molecular pharmacology of the P2Y2 R in living cells. Additionally, the role holder will characterise the molecular pharmacology of physiologically relevant P2Y2 R alternative transcripts and a series of point mutations of residues implicated in ligand binding, receptor expression and downstream signalling. 

Candidates should have a PhD (or close to completion) or equivalent in pharmacology or a related discipline, along with a proven track record of molecular pharmacology research and experience with the study of G protein-coupled receptors in living cells. Experience in resonance energy transfer assays and quantitative downstream signalling assays is also required. 

The successful candidate will join a vibrant molecular pharmacology focused research group embedded within the Centre of Membrane Proteins and Receptors (COMPARE) at the University of Nottingham. COMPARE is a joint initiative between the Universities of Nottingham and Birmingham using imaging to study membrane bound receptors https://www.birmingham-nottingham.ac.uk/compare/ . 

This is a full-time (36.25 hours), fixed-term post for 6 months from 1st July 2026. Requests for secondment from internal candidates will be considered on the basis that prior agreement has been sought from both your current line manager and the manager of your substantive post, if you are already undertaking a secondment role.

Informal enquiries may be addressed to Professor Stephen Hill: steve.hill@nottingham.ac.uk  or Dr Laura Kilpatrick: laura.kilpatrick@nottingham.ac.uk . Please note that applications sent directly to these Email addresses will not be accepted.

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