Call for a Postdoctoral Fellow for Proteostasis Lab at Keio University WPI-Bio2Q (PI Nadinath Nillegoda, PhD)

Organisation/Company

Keio University

Department

Human Biology Microbiome Quantum Research Center(Bio2Q) Bio2Q Office

Research Field

All
Other

Researcher Profile

Recognised Researcher (R2)

Application Deadline

29 May 2026 - 23:59 (UTC)

Country

Japan

Type of Contract

Permanent

Job Status

Not Applicable

Hours Per Week

See description

Is the job funded through the EU Research Framework Programme?

Not funded by a EU programme

Is the Job related to staff position within a Research Infrastructure?

No

[Background of the recruitment and description of the project]
* Background of the recruitment and description of the project
Our laboratory investigates proteostasis network pathways that safeguard cellular and tissue integrity following protein damage. A central focus of the group is understanding how these pathways promote cellular repair, tissue resilience, and organismal health during aging. We are pioneers in the emerging field of primate proteostasis, and were the first to examine how primate-specific adaptations in protein quality control networks influence cell repair mechanisms and contribute to human disease, protein aggregation, and age-related decline.

Transplantation biology is a cornerstone of modern medicine with profound implications for healthy aging. The long-term success of cell and tissue transplantation depends not only on immune compatibility, but also on the intrinsic ability of transplanted cells/tissue to withstand proteotoxic stress encountered during isolation, engraftment, and long-term tissue integration. Impaired proteostasis severely compromise transplantation outcomes and may directly limit graft longevity and function. Understanding and enhancing cellular resistance to protein damage therefore represents a fundamental opportunity to improve transplantation success and durability, with broad implications for regenerative medicine and age-related disease.

In close collaboration with world-renowned clinicians and scientists at Bio2Q and Keio University School of Medicine, our group is leading efforts to modulate cell and protein repair pathways to enhance cell/ tissue transplantation outcomes. Our work explores a novel and transformative dimension of transplantation biology, with the potential to significantly improve the longevity and resilience of transplanted biologics.
https://www.bio2q.keio.ac.jp

[Work content and job description]
We are seeking a highly motivated and skilled Postdoctoral Fellow to lead this innovative research program at the interface of proteostasis and transplantation biology. The successful candidate will have strong expertise in stem cell biology, cell/tissue transplantation biology, advanced imaging, and animal (mouse) work. This position offers a rare opportunity to define a new research direction with high translational relevance, enabling rapid and impactful discoveries that could substantially improve transplantation outcomes and promote healthy aging.

The Postdoctoral Fellow will work closely with the Principal Investigator and engage in active collaboration with an interdisciplinary team of clinicians and basic scientists. These collaborations provide access to state-of-the-art technologies, experimental systems, and clinical perspectives, allowing the candidate to acquire valuable skills and establish a strong independent research profile.

* Assigned department
Existing departments

[Work location]
* Address
160-8582 Tokyo Shinjuku-ku, Shinanomachi
The successful applicant will work at the host laboratory within the Bio2Q research center located at 35 Shinanomachi, Shinjuku-ku, Tokyo 160-8582, Japan.

[Number of hired]
Number of hired:1 person(s)
Job content supplemental explanation:Start date: The candidate must be ideally available to start in early-mid 2026. The exact dates are negotiable.

Website

https://jrecin.jst.go.jp/seek/SeekJorDetail?fn=0&ln=1&id=D126011606&ln_jor=1

[Compensation]
Annual salary:6 million yen - 7 million yen
Wages description:The annual salary will correspond to years of experience, ability, and performance.
Model annual salary: 6,000,000 – 7,000,000 JPY
Working hours:08:30-17:00
Break time:11:30-12:30
Holidays :Days off include Sundays, national holidays, year-end/New Year holidays, and Keio University holidays (January 10, etc.).
Overtime and other explanations:Working on Sundays and holidays may sometimes be required.
Employment type:Contract employee
Contract period:Nontenured
Contract period description:(1) The contract is a three-year fixed-term employment contract and is subject to review each fiscal year. The contract is eligible for renewal based on performance and mutual agreement between employer and employee.
(2) The renewable term is subject to change depending on the continuation of the WPI program, Bio2Q's management situation, budget situation, and other factors. In principle, the contract will not be renewed beyond the age of 65.
Probationary period:Probationary period absent

[Various systems]
Transportation expenses:available

[Insurance]
Employees' Health Insurance:available
Employees' Pension Insurance:available
Worker's accident insurance:available
Employment insurance:available

[Measures for preventing passive smoking at the workplace]

[Supplementary explanation of compensation]

Number of offers available

1

Company/Institute

Keio University

Country

Japan

City

Tokyo

City

Tokyo

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