Postdoc in Cancer Biology and Microenvironment

Our laboratory has one position available for postdoctoral fellow in the area of Cancer Biology and Microenvironment. We are interested in mechanisms of tumor initiation and resistance, with an emphasis on tissue long lived cells such as stromal cells, and their crosstalk with tumor cells, immune cells and the vasculature. We perform mostly in vivo studies, combining lineage tracing and depletion models, flow cytometry, confocal microscopy and unbiased approaches such as single cells transcriptomics, spatial transcriptomics and epigenetics to characterize molecular and cellular mechanisms. Using these approaches, we previously identified an essential role for specific subsets of stromal cells in tissue repair and antitumor immunity (Dulauroy et al., Nature Medicine 2012; Stzepourginski et al., PNAS 2017; Jacob et al., Cell Stem Cell 2022; Di Carlo et al., Nature Immunology 2023). Building on these findings, we aim at identifying novel mechanisms regulating the tumor microenvironment and antitumor immunity, with a focus on solid tumors such as breast cancer and lung cancer.

For more information and to apply, send a motivation letter, CV and contact information for 2 references to Lucie Peduto (lucie.peduto@pasteur.fr ).

Required qualifications: Recent PhD degree (including in late 2025) in tumor biology, vascular biology, immunology or related biomedical field, with at least one accepted publication and lab experience in one or more areas that include: breast cancer, lung cancer, antitumor immunity, vascular biology, stromal/mesenchymal cells. Highly motivated candidates with interest in areas of research at the intersection of tumor biology, the stromal microenvironment and immunology are strongly encouraged to apply. Specific requirements:

• Required : Solid experience with in vivo cancer murine models (breast cancer and/or lung cancer) and flow cytometry
• Desirable : Previous experience in transcriptomic analysis (scRNAseq), scripting languages (R) and Seurat.
• Would be a plus : Previous experience in epigenetic analysis

The position is available starting immediately. Benefits include comprehensive healthcare coverage and 6 weeks paid annual leave. Research will be conducted at Institut Pasteur in the center of Paris, which contains state of-the-art facilities and a highly collaborative research environment with 13 Departments across Biology/Physics/Biomedical fields.

Recent publications of the lab:

• PDGFRα-induced stromal maturation is required to restrain postnatal intestinal epithelial stemness and promote defense mechanisms. 2022. Jacob et al., Cell Stem Cell, 29(5): 856-868.
• Depletion of slow-cycling PDGFRa+ ADAM12+ mesenchymal cells promotes antitumor immunity by restricting macrophage efferocytosis. 2023. Di Carlo et al., Nature Immunology, 24(11):1867-1878.