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to conduct clinical research with human eye specimens. Our work spans three major directions: * Basic Research: we investigate the cellular and molecular mechanisms of ocular tissue development and homeostasis
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Scheduled Hours 40 Position Summary The Ushiki Lab investigates the molecular mechanisms of transcriptional regulation and how noncoding genetic variation alters gene regulation in human disease
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, the causative agent of cholera. We perform detailed studies using specimens derived from human samples. Projects include: Creating knock-out mutants to study how V. cholerae virulence is impacted by gut bacteria
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Position Summary The Ushiki Lab investigates the molecular mechanisms of cis-regulatory function and how noncoding genetic variation alters gene regulation in human disease. Our work integrates
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progression. These projects utilize a wide breadth of technologies from single cell sequencing to mass spectrometry to high throughput, quantitative imaging. In addition, we use human genetics, AAV viral
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infection. We focus on defining host pathways that can be therapeutically leveraged to target the HIV reservoir. Our work integrates molecular virology, primary human cell systems, and in vivo models. We
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. * Human translational validation using the VDAART randomized clinical trial cohort (prenatal vitamin D supplementation, childhood cardiometabolic outcomes, methylation arrays). * Developmental programming
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researchers, to translate findings across model systems and human cohorts. Mentor junior lab members, including graduate students and research staff, and contribute to fostering a supportive and rigorous
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pregnancy outcomes and cardiometabolic recovery among patients with adverse pregnancy outcomes. We welcome applicants with a strong background in human nutrition and metabolism and an interest in integrating
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, Data science, Statistical Genomics or a related discipline involving the interrogation of ‘omics’ datasets. Hands-on experience with large-scale human omics (preferably related to neurodegeneration