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chromatin remodelling complexes, and benchmark their activities generate nucleosome positioning maps using sequencing-based readouts (e.g., MNase-seq, Fiber-seq) and perform quantitative data analysis
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regulation by integrating crosslinking mass spectrometry, cryo-electron microscopy, and structural modeling. The project seeks to map how protein complexes exist in their native cellular environments a central
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multimodal data analysis. Over the past decade, our institute has pioneered exome and genome sequencing in order to map the genomic landscape of male infertility, particularly focusing on non-obstructive
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computational prediction, mapping, and functional characterisation of promoter sequences. Demonstrated expertise in measuring plant photosynthesis and performing plant growth assays under both optimal and abiotic
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, quantitative peptide profiling, site-specific post-translational modification mapping, and validation of cofactor maturation and incorporation into target proteins Demonstrated experience in in vitro enzyme
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to systematically map genetic interactions, and we continue to develop new screening approaches that expand what's possible. Fibroblast plasticity and ECM in disease: Fibroblasts take on harmful states
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methods, including UAV-based landscape mapping, terrestrial and freshwater eDNA, passive acoustic and camera monitoring, and novel sensor and logger networks for real-time analysis of greenhouse gas
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discoveries to the lab to gain biological in-sights into preterm delivery. Our group has started mapping variants to specific gene targets in en-dometrial stromal cells (2d cell culture). The postdoc’s project
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, ATAC-seq, CUT&RUN, MERFISH, Visium), epigenomic data processing (chromatin accessibility, histone marks, enhancer mapping), multi-omics integration using Seurat, Signac, Harmony, ArchR or Scanpy, machine
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Nature). Condensates, Chromatin and Translational Control in Pediatric Cancer (Grebien Lab ). We develop quantitative and functional approaches to map how leukemia-driving oncoproteins act in the context