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rates, DNA damage repair, epigenetic mark inheritance, and transposable element silencing. The lagging strand, in particular, may represent a key source of (epi)genetic instability under pathological
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, culture, and genetic manipulation of mouse embryos; biophysical techniques such as high-resolution microscopy, optical tweezers, and microfluidics; as well as image and data analysis. The Institut Curie is
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-synaptic elements Targeted genetic manipulations of the neurons studied Analytical activities Extraction and analysis of transcriptomic data (RNA-seq) from single cells Bioinformatic analyses related
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leading multidisciplinary public research organizations. The IGBMC (Institute of Genetics and Molecular and Cellular Biology), one of Europe's leading biomedical research centers, is a joint research unit
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. - Establish a genetically modified mouse model of liver fibrosis. - Manage animal breeding and genotyping. - Conduct cold plasma treatment experiments in the animal facility and perform post-treatment tissue
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. Proven experience in advanced flow cytometry, confocal microscopy, and/or NGS methodologies is essential. Relevant specialized experience in molecular and cellular biology, molecular genetics, and in vivo
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high-resolution microscopy • Mammalian cell culture and genetic manipulation • Molecular and biochemical assays • Quantitative analysis of intracellular trafficking dynamics The project will be carried