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of rare neurological diseases in childhood as well as the management and therapy of the affected patients. Your responsibilities You will examine the molecular mechanisms of inherited neurological diseases
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of rare neurological diseases in childhood as well as the management and therapy of the affected patients. Your responsibilities You will examine the molecular mechanisms of inherited neurological diseases
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at unprecedented resolution. The core innovation of your work will be integrating this data to train deep learning models that predict chromatin accessibility and gene expression patterns. These models will
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to improve chimeric antigen receptor (CAR) T cell therapies by targeting genes and gene-regulatory processes to prevent CAR T cell dysfunction. Your tasks include but are not limited to: CAR T cell design and
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. To that end, we are leveraging the latest advances in gene therapy to engineer long-lived host cells to continuously produce HIV-1 IgG therapeutics in vivo at levels sufficient to prevent viral replication in
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Postdoctoral Positions for Computational Genomics, Cancer Genetics, and Translational Cancer Biology
recurrent gene fusions (ESR1-CCDC170, BCL2L14-ETV6, RAD51AP1-DYRK4) and intragenic rearrangements (IGRs)—a largely unexplored class of genetic aberrations. Precision immuno-oncology: Develop next-generation
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contexts, and using CRISPR activation and interference to identify specific genes that contribute to disease pathology. The successful candidate will gain expertise in stem cell biology, genome engineering
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-derived models, performing comprehensive differentiation studies across multiple cellular contexts, and using CRISPR activation and interference to identify specific genes that contribute to disease
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progression and therapy resistance. This position will leverage cutting-edge approaches including spatial transcriptomics, CRISPR-based functional genomic screening, and patient-derived xenograft (PDX) models
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Research Therapeutic Area, focused on discovering targets and validating and developing therapies for neurodegenerative diseases including Alzheimers and Parkinsons Disease. This position is laboratory-based