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biophysical (e.g., FRET, ITC, SPR) and structural techniques (e.g. cryoEM) to characterize protein interactions Background in membrane biology or lipid biochemistry. Knowledge of neuroscience or synaptic
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-molecule and FRET if this avenue proves fruitful. Not all of these initiatives will bear fruit, and several will be allocated to other group members, but the forgoing are aims of the projects supporting
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-clamping (mandatory) and Ca2+ imaging as well as FRET; test hypotheses and analyse scientific data from a variety of sources; and collaborate in the preparation of scientific reports and journal articles and
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engineering to measure the structural and dynamic properties of individual biomolecules using spectroscopic techniques such as single-molecule Forster Resonance Energy Transfer (FRET) and cryogenic electron
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or a closely related field. Hands-on experience in constructing custom fluorescence microscopy systems (e.g., FRET, FLIM, FCS, and anisotropy). Solid understanding of time-resolved fluorescence
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techniques, to investigate cellular trafficking and activity of RAS pathway proteins in cells, including confocal-/ super-resolution microscopy, interaction studies (complementation, BRET and FRET), protein
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microscope, single molecule TIRF microscopy and analysis of RNA-protein interactions by techniques including FRET. Length of advert - 2 weeks About you You will hold a high‑quality first degree and PhD in
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for the cascade (building on initial discoveries in our group), (ii) apply one or more biophysical methods, such as microscale thermophoresis, ITC, fluorescence polarisation, single-molecule FRET, to characterise
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imaging Analyze complex datasets (kinetics, FRET traces, colocalization) Initiate and drive new subprojects Mentor PhD students and collaborate closely within the group and with partners abroad Present
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protein engineering, characterization of protein interactions by various methods, de novo design of protein binders, integrative structural biology using NMR, SAXS and/or single molecule FRET. Your profile