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Field
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for the cascade (building on initial discoveries in our group), (ii) apply one or more biophysical methods, such as microscale thermophoresis, ITC, fluorescence polarisation, single-molecule FRET, to characterise
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qualifications An M.D., Ph.D. or M.D./Ph.D. is required Preferred qualifications Candidates with a background in vascular biology, cell and developmental biology, mouse genetics, fluorescence microscopy and/or
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, and fluorescent microscopy. Experience in studying skin, hair follicle, skin cancer, or epithelial-mesenchymal interaction, and genetically engineered mouse models is a plus. The ideal candidate should
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-molecule metabolite signatures. Design and optimisation of fluorescent probes, high-throughput biochemical assays, and chromatographic and mass spectrometry-based platforms for quantitative biomarker
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for mitochondrial mRNA levels and degradation using a fluorescent microscopy-based approach. The proteins identified in this screening will be further characterized through various molecular, biochemical, and
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-molecule TIRF microscopy, biochemical reconstitution, and fluorescent labeling, we will watch individual RNA molecules and degradosome complexes at work, capturing millisecond-scale dynamics that shape gene
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force microscopy (AFM), advanced fluorescence and confocal microscopy, and quantitative biophysics. The project aims to elucidate how mechanical properties and forces emerge from molecular and structural
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that are properly folded and competent for protein translation. Force spectroscopy (optical and magnetic tweezers), single-molecule fluorescence, and bulk biochemical methods will be used to investigate how
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to the subject area. Applicants must have documented research experience in molecular genetic approaches, fluorescence microscopy, mammalian cell culture, and intracellular infection models. Experience in
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experiments group (You+Supervisor+support by lab). These collaborations enable practically relevant and breakthrough results. This team goal requires initially videomicroscopy of X-Y fluorescently labeled sperm