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pathophysiology that results from genetic mutations in mitochondrial proteins, chromatin regulators, and metabolic enzymes. We interpret our experiments in the context of curated clinical phenotypes and validate
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. Science 2024), we aim at a deeper understanding of the interplay between subcellular localization of metabolic enzymes, chromatin structure, and transcriptional regulation. Microbiota dysbiosis, increased
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the research group and use this method in your own research project. This project will revolve around the expression and distribution of metabolic enzymes, in close collaboration with the HPA team. We
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enzyme-like reactivity with high efficiency and selectivity. The project concentrates on elucidating structure-performance relationships in carbon electrocatalysts and on designing highly active materials
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– design and development of engineered and artificial enzymes for biocatalysis and asymmetric synthesis Projects – involve biocatalysis, protein engineering/directed evolution/design, and mechanistic
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regulation of nuclear xenobiotic receptors, (2) the mechanism of selective modulation of highly homologous drug-metabolizing enzymes. We are taking a hypothesis-driven and technology-enabled multidisciplinary
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biodiversity Strong expertise in the extraction and characterization of enzymes Demonstrated expertise with isolating, culturing, and experimenting with various fungal species from field samples Experience in
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as this is a principal goal of the Sharifi Laboratory. For example, we have shown that our discovery of a gain-of-function in a steroid-synthesizing enzyme is a predictive biomarker of poor outcomes
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to cutting-edge resources and core facilities. Potential projects encompass the characterization of novel mutant animal and cell culture models showing cell autonomous effect of lysosomal enzyme deficiency in
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for cancer, neurological diseases, and more, as well as new vaccines, nanomaterials, and enzymes. This is a full-time position(s) with a 12-month service period, with the possibility for yearly renewal