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Field
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force microscopy (AFM), advanced fluorescence and confocal microscopy, and quantitative biophysics. The project aims to elucidate how mechanical properties and forces emerge from molecular and structural
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facilities, who are developing complementary microscopy and AI/ML workflows, ensuring that multimodal datasets (X-ray, electron microscopy, and spectroscopy) are well-aligned and interoperable. These positions
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, or appropriate experience or equivalent qualification and/or experience. Knowledge of the day to day workings of an immunology laboratory, including microscopy, tissue culture and molecular biology would be
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will also use focussed ion beam milling scanning electron microscopy (FIB-SEM) to prepare infected cells for in situ cryo-ET. The resulting tomographic data will be analysed by machine-learning assisted
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microscopy, and protein structure prediction by artificial intelligence algorithms. The goal is to generate functional models of multimeric protein complexes and how they assemble as a guide to understand
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. Structural biology using electron microscopy, such as cryogenic electron microscopy (cryo-EM) and tomography (cryo-ET). The postdoc will be central for helping to grow the new lab and will collaborate closely
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fibrosis, in vitro and in vivo testing therapeutic candidates, scRNAseq, spatial transcriptomics, confocal and electron microscopy imaging, flow cytometry, and standard biochemical/molecular approaches. Our
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experimental approaches for structural biology (e.g., cryo-electron microscopy/tomography, X-ray crystallography) is a significant plus. Experience with antibody engineering (e.g., expression, stability, binding
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laboratory. Transmission electron microscopy will be used for a structural, chemical, and electronic study of high electron mobility transistors (HEMTs) based on Niobium nitride (NbN) as part of this contract
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, biochemistry, or a related field Hands-on experience in cryo-electron microscopy for the determination of protein structures Experience in amyloid structure determination, electron tomography, and