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sorghum, using new whole genome CRISPR screening techniques that the lab has developed. The project is in close collaboration with computational approaches that model the genes and circuits that make cells
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-targeting CRISPR systems (Zolboot et al. in preparation), and single-cell, isoform-sensitive measurements of translation in vivo (Ribo-STAMP; Sison et al. Nature 2026). Using these tools, we have identified
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molecular biology and immunology techniques along with multi-omics approaches, including sc-RNA-seq, bulk RNAseq, epigenomics, metabolomics, proteomics, CRISPR screens and genetically engineered mouse models
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for Neuroscience . The Verstreken lab is developing advanced multielectrode array systems to mimic human brain circuits relevant to neurodegenerative disease. They are also conducting advanced CRISPR screens
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differentiation, iPSC engineering, large-scale DNA assembly and characterization, genetic recombination and site-specific genome integration (e.g., CRISPR/Cas9, RMCE), next-generation sequencing, computational
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Communications 2024), and are now expanding into using spatial biology, in vivo CRISPR screening and genetic barcoding approaches to identify additional context-specific pharmacological vulnerabilities, tumour
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) and therapeutically tractable tumour-microenvironment interactions (Andrade et al., Nature Communications 2024), and are now expanding into using spatial biology, in vivo CRISPR screening and genetic
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. These modelling approaches will be combined with advanced phenotyping and single-cell genomic analyses, including multi-omics and transcriptomics, as well as functional interrogation through CRISPR/Cas9 screening
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hematopoiesis and hematologic malignancies is desirable. Previous experience with CRISPR technology and/or CRISPR screens will be considered as an advantage. Be willing to work with mice and/or be comfortable
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applicants will lead a project focused on leveraging exciting newly developed experimental tools, including novel CRISPR-dCas9 epigenetic screens and cerebral organoid co-culture systems applied to patient