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Field
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-leading research in several fields. Notably, the groundbreaking discovery of the CRISPR-Cas9 gene-editing tool, which was awarded the Nobel Prize in Chemistry, was made here. At Umeå University, everything
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practical experience of state-of-the-art molecular biology techniques and data analysis. In particular expertise in the following is essential : Genome editing, Epigenome editing, Off-target analysis, CRISPR
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(e.g. RNAi, CRISPR/Cas9, small-molecules). In this context, we also develop new computational tools for automated analysis and data visualization. These include algorithms and software applications
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expertise, we are creating functional genetic maps using conditional CRISPR/Cas9-based single and higher-order knockout perturbations combined with single-cell expression profiling and imaging. We expect
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, and resistance, and potentially assess candidate functions using CRISPR and transgenic approaches. Anticipated Division of Time Research (55%): The Postdoctoral Associate will play a leading role in
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-leading research in several fields. Notably, the groundbreaking discovery of the CRISPR-Cas9 gene-editing tool, which was awarded the Nobel Prize in Chemistry, was made here. At Umeå University, everything
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progression and therapy resistance. This position will leverage cutting-edge approaches including spatial transcriptomics, CRISPR-based functional genomic screening, and patient-derived xenograft (PDX) models
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. What we work on: CRISPR screening at scale: We co-developed the Perturb-seq approach for conducting single-cell CRISPR screens. We’ve since scaled this technology to target every gene in the genome and
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assess candidate functions using CRISPR and transgenic approaches. Anticipated Division of Time Research (55%): The Postdoctoral Associate will play a leading role in conducting experimental, computational
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for analysis of large-scale whole genome genetic and genomic and phenotype data. Examples include large Whole Genome Sequencing association studies, biobanks, single-cell and CRISPR multiome data, integrative