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mechanisms that could constitute relevant targets for new treatments. We are leading the genetic work package of AIMS-2-TRIALS, the largest European project on autism research. The project is focused on deep
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will create mutant of the parasite targeting a specific protein and explore its role in sugar homeostasis with a specific emphasis on nucleotide sugars. Qualifications: The applicant will hold a PhD in
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biofluids, tissues and faeces hydrophilic interaction (HILIC) and reverse phase (C18) chromatographies and high-resolution mass spectrometry • Development of targeted isotopic quantification methods
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targets. Main activities: - Bioinformatic analysis of WES and RNA-seq data. - Variant calling, annotation, and mutational signature analysis. - Differential gene expression and pathway analyses
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potential therapeutic targets and biomarkers. An ambitious technological development in the team focuses on single cell proteomics analysis to access tumor heterogeneity in patient-derived organoids and
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University Foundation, aims to develop self-assembling and water-soluble artificial mini-proteins with bioinspired heme&Trp redox cofactors for targeted catalysis, and resulting in novel versatile catalysts
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in new mouse models with lymphatic endothelial cell (LEC)-selective deletion of target genes using tissue clearing and confocal and light sheet microscopy with help from technical staff at the imaging
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media requires the development of approaches targeting intermediate scales of matter, between the nanometer and the micrometer, using both experimental tools for synthesis and characterization, often in
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the metabolic properties of osteoclasts during development and aging using preclinical models with targeted alterations in specific metabolic pathways. - To implement single-cell biology approaches and
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of researchers, physicians, pharmacists, and engineers, and focuses on corneal diseases, from understanding physiopathological mechanisms to developing targeted therapeutic strategies. Scientific context