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. These coordinated hormonal activities influence not only the rate of cell division but also the duration and dynamics of each phase of the cell cycle. With the advent of advanced technologies, such as single-cell
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of the cell cycle. With the advent of advanced technologies, such as single-cell genomics and live-cell imaging, we can now explore hormone regulation at unprecedented single-cell resolution. Using these tools
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and Saeys teams. In this research project you will develop and apply algorithms to link clinical phenotypes of metastasis to molecular phenotypes in mouse models. It is known that metastases exhibit
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data. We have developed in vivo single-cell CRISPR technologies to screen for dozens of molecular factors in vivo during developmental and disease. These technologies are a game-changer in the speed
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morphology to directly link gene-regulatory cell states to functional neuronal phenotypes. This ambitious project integrates wet-lab experimentation with advanced computational analysis, and is ideal for a
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to state-of-the-art facilities and training in advanced techniques. Opportunities for career development, networking, and mentorship. A highly stimulating and supporting international research
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role in membrane remodeling. It also aims to deepen the mechanistic understanding of solute transport in ion channels and transporters of medical relevance. We apply state of the art methods
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image analysis and/or coding (e.g. Python) Exposure to TEM/cryo-EM/cryo-ET or advanced fluorescence microscopy Experience handling human-derived samples (reproductive cells/tissues) What we
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, proteomics, microscopy, structural biology, technology development, and bioinformatics at VIB-UAntwerp Center for Molecular Neurology (https://cmn.sites.vib.be/ ), at VIB (https://vib.be/ ), and at UBirmingham