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& molecular analyses: Targeted microdissection of abnormal cells from Giemsa smears, extraction of DNA/RNA and molecular genetic analyses (e.g. targeted NGS, qPCR) to identify resistance genes and mutations
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cells; 2) Model AML plasticity at the single-cell level; 3) Propose candidate therapeutic targets for in vivo validation. The PhD student will be embedded in a collaborative and supportive team, working
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lines; generation of samples for proteomics analysis Data integration and analysis, including transcriptomic, proteomic and library screen data Target validation by CRISPR-Cas9 knockouts in primary AMLs
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) representation (Research Field “Staging Enmity")and (3) physical encounters (Research Field “Enemy Contact”). Our research regions include Europe, Asia and the Middle East. The RTG Ambivalent Enmity targets
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adults, characterised by severe genomic instability and a lack of targeted therapies. Using cutting-edge methods and unique primary patient-derived cell models, this project will seek to understand
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on the underlying molecular causes of cardiovascular diseases and the targeted development and translation of molecular therapies for clinical applications in cardiovascular diseases. The innovative research project
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sterilization protocols, qualifying them as important persistence factors and potential drug target. Elucidating their regulatory and working mechanisms will provide important information for potential future
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. Strong interest in advanced neurofunctional assessments and methods (e.g., computer vision, bioacoustics, machine learning/AI, neuroimaging, eye-tracking, multimodal data fusion) and/ or willingness