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cell tracking to identify the progenitors of these cells during regeneration. • Develop and apply a recombinase-based cell barcoding strategy to trace cell lineages during leg growth and regeneration
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issues faced by the endosymbiont. Such import relies on organelle targeting peptides (oTPs) at the N-terminus of most organelle targeted proteins. These oTPs enable passage across the organelle envelope
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to pathological processes, most notably cancer progression. By targeting and degrading Cathepsin D, this project aims to establish an innovative therapeutic strategy for triple negative breast cancer, while also
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Description The objective will be to identify the most likely protein candidates among microbe–human pairs as targets for further comprehensive investigation. This challenge will be addressed by developing and
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of target species, and 2) identify and map the risk of interactions between sea turtles and fishing gear. Main tasks: - Processing accelerometric/gyroscopic and acoustic signals related to the fine behaviors
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** Deployment and optimization of the PFAS analytical toolbox: targeted analyses (LC-MSMS, GC-MSMS), total oxidizable precursor assay (TOPFAS), and non-target screening (NTS, LC-HRMS Orbitrap). Intercomparison
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molecular model-ing studies at varying levels of precision: • using force field (MF) modeling for interaction models between the target enzyme and different substrates; • using Quantum/Classical Mixed Method
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they can be targeted to improve senescence-related pathologies. Recent lab publications: -Margand C et al. Emerging role of mitochondrial calcium levels in cellular senescence and in switching cell fates
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of ABC-F proteins are often found within a genome, suggesting different functions for each paralog (Fostier et al., FEMS Letters 2021). Recently, we showed that the ABC-F protein EttA targeted
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interference effects and more realistic, correlated disorder models, in order to determine whether it can lead to dynamical localization in energy. The work will primarily target one-dimensional systems