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breadth PPIs, yet do not provide information on how proteins interact with each other. In fact, only for about 5% of all known human PPIs a structure of the interaction has been resolved. This lack in
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the following PhD project: R-loops are three-stranded nucleic acid structures comprising an RNA hybrid and a displaced single-stranded DNA (ssDNA). The exposed ssDNA makes R-loops a hotspot for DNA modifications
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PhD project: R-loops are secondary DNA structures consisting of an RNA-DNA hybrid and a single stranded DNA that can form behind the elongating RNA polymerase II during transcription. R-loops play
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. These modifications can affect DNA structure, gene expression, and genome stability. Cytosine methylation (5mC) has been extensively studied, but less is known about the biological roles of its oxidized forms
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acid structures comprising an RNA hybrid and a displaced single-stranded DNA (ssDNA). The exposed ssDNA makes R-loops a hotspot for DNA modifications that can impact R-loop dynamics, gene regulation and
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, to how epigenetics regulates cellular identity or neural memory. Activities and responsibilities The research group of Petra Beli offers the following PhD project: R-loops are secondary DNA structures
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cytosine methylation and its oxidized derivatives (e.g., 5-formylcytosine [5fC]), play essential roles in gene regulation and epigenetic programming. These modifications can affect DNA structure, gene
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modulate seedling development in a light-dependent manner. PhD project: Regulation of alternative splicing by R-loop formation in Arabidopsis R-loops refer to RNA-DNA hybrid structures that have been linked
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project: Regulation of alternative splicing by R-loop formation in Arabidopsis R-loops refer to RNA-DNA hybrid structures that have been linked to genotoxic stress. More recently, R-loops have also been