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coordinated mechanisms, which include DNA Damage Response (DDR), the control of cellular proliferation or apoptosis induction. IR exposure might lead to genomic instability, chromosomal aberrations and cancer
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, England P, Gielen M, et al. ‘An Original Potentiating Mechanism Revealed by the Cryo-EM Structures of the Human Α7 Nicotinic Receptor in Complex with Nanobodies’. Nature Communications 14, no. 1 (25
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surveillance by the unfolded protein response (UPR), a major adaptive mechanism that lies at the core of cellular homeostasis and is responsible for cellular life-or-death decisions. The Inositol-requiring
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cancer cells and in the macrophages within their tumor microenvironment. Our goal is to unravel the intricate mechanisms behind AIM2's recruitment to DNA-laden structures and explore the role of AIM2