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including fragmentomics, methylomics, etc). In addition, results will be compared and integrated with bulk and single-cell/spatial data obtained on matching tumor cells. About TOBI-lab The overarching goal
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training data. You will unravel the cis-regulatory code controlling context-dependent gene expression and use this information to design synthetic promoters. You will train and evaluate predictive models in
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intervention trials (e.g., diet, FMT), and ex vivo gut models enabling advanced multi-omics analyses of these samples. In addition the lab also maintains a large culture collection, partially linked to genomic
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identity and establish proper connectivity with brain targets during development. To this end, Esther and her team use advanced technologies like single-cell and spatial transcriptomics and connectomics
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critical roles of ion channels—particularly the TRP superfamily—in physiological and pathological processes. Our interdisciplinary approach spans from foundational electrophysiology to translational models
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are seeking a motivated and enthusiastic colleague with strong computational skills in the analyses of complex data sets to join our teams. About the project We have generated advanced brain on chip models
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the fundamental aspects of transcriptional control, this project also opens new avenues for the design of climate-resilient crops. Supported by single-cell profiling and predictive artificial intelligence models
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-scale screens to study fundamental principles in molecular and complex trait genetics using microbes as model systems. Our core technology MAGESTIC (https://doi.org/10.1038/nbt.4137 ), a CRISPR/Cas9-based
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single-cell and spatial multi-omics datasets. The primary focus of this role is to delve deeper into the molecular mechanisms driving intra-tumor heterogeneity, plasticity, and therapy resistance
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project that combines cutting-edge approaches including state-of-the-art imaging techniques, pluripotent stem cell models, in vivo mouse models of neurological disorders, drug (brain) delivery and nanobody