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monitoring and profiling of breast tissue and systemic responses; Use of mouse models to study early tumour initiation; Application of single cell and spatial transcriptomics, lineage tracing, and multiomics
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bronchoscopy samples and tissue. Spatial transcriptomics will be used to characterise cellular populations, functional cell states and cell- cell interactions. To validate epithelial-immune cell interactions in
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bronchoscopy samples and tissue. Spatial transcriptomics will be used to characterise cellular populations, functional cell states and cell- cell interactions. To validate epithelial-immune cell interactions in
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Institute for Molecular and Computational Medicine (IMCM). You will test GSK assets and targets in established models of podocyte and mesangial cell pathology relevant to glomerular diseases. You will
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, a spatially-explicit agent-based model of land use change in Great Britain. This will be coupled with a system dynamics model of macro-scale drivers of land system change. Working with colleagues from
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, a spatially-explicit agent-based model of land use change in Great Britain. This will be coupled with a system dynamics model of macro-scale drivers of land system change. Working with colleagues from
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tract, how immunity develops in early life, and how it goes awry in devastating inflammatory diseases such as necrotising enterocolitis and inflammatory bowel disease. Spatial ‘omics and single cell
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proteome in heart-specific cell lines and primary tissue. It will utilize disease model systems to characterize unique cell surface signatures for cardiomyocytes, coronary endothelial cells, and fibroblasts
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proteome in heart-specific cell lines and primary tissue. It will utilize disease model systems to characterize unique cell surface signatures for cardiomyocytes, coronary endothelial cells, and fibroblasts
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material, binder, etc) and overall microstructure is controlled to vary spatially within the electrodes. These models will then be used to find a design that maximises the overall performance balance (energy