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understanding on the origin of nucleic acids that are shed in liquid biopsies, such as blood, using cancer models (mouse and rat) and patient samples of neuroblastoma disease, a rare childhood cancer. Nucleic
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drive neuroinflammation in synucleinopathies and other neurodegenerative diseases. The candidate will employ advanced in vivo models and spatial technologies to dissect the roles of tissue-resident
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candidate will work closely with experts in food allergy, neuroimmunology, gut physiology, and computational biology to characterize immune cell responses, construct spatial maps of inflammation along the gut
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this disease and reveal the mechanisms underlying the strong cell-type specific effect of the CMT-causing YARS mutations. For this we will generate high-resolution spatial chromatin organisation, chromatin