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Field
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genomics, spatial metabolomics, single-cell sequencing, Optical/Photoacoustic imaging, seahorse, WB, RT-PCT, immunostaining and data analysis related to these assays. The experiments also include using cell
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, spatial, and social data into digital twin models for scenario testing and policy simulation. Adapt co-design methods to local contexts in demonstrator sites (Portugal, Sweden, Italy). Contribute to policy
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, but starting time is flexible. Focus of the project is the investigation of the link between the dynamics of synaptic structural plasticity and the probability of neurons to become active during spatial
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This project explores how mutations in chromatin-modifying genes disrupt early neurodevelopment by systematically profiling in vitro neurons using multimodal single-cell and spatial profiling. By
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. The successful candidate will: 1) Lead the development of computational pipelines for the integration of large-scale single-cell omics datasets, including single-cell CITE-seq, scATAC-seq, and spatial
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3D cell cultures under several perturbations Develop and apply methods for the analysis of the cellular proteome both at cell type, and single-cell level, based on imaging results and recent spatial
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, and advanced data analysis. This role is part of a large-scale, multi-institutional consortium study aimed at uncovering novel insights into the genetic and molecular underpinnings of neurodevelopmental
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3D cell cultures under several perturbations Develop and apply methods for the analysis of the cellular proteome both at cell type, and single-cell level, based on imaging results and recent spatial
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to recreate human intestinal inflammation, establishing a novel pharmacological platform for preclinical drug evaluation. Evaluate disease trajectory and predictive potential through comparative spatial
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with or managing research activities, and preparing reports. Strong skills in statistical analysis and handling large spatial and temporal datasets. Good communication skills for collaboration within