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musculoskeletal tissues are mechanosensitive, meaning that they adapt to the local mechanical loading. We have earlier shown that the collagen fiber structure is affected by unloading of the tendon in a small
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will work on developing global fit algorithms for use in the LISA data processing. This will involve adapting existing simulation software to test and develop new algorithms and to investigate how
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cost-efficiency in supply chains; centralised versus decentralised storage and distribution; and short-term food security needs versus long-term circularity and environmental goals. This shift is vital
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pathological forms of the protein. Techniques involved will include X-ray and neutron crystallography, small-angle scattering (SAXS & SANS), and cryo-EM. The work will involve the study of wild-type TTR (which
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-TEM imaging. One a functional design is at hand, the work will be focused on structure determination using cryo-EM of one test case of know structure, followed by a test case of partially know structure
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regular visits to national imaging facilities, such as MAX IV in Lund, and partner cryo-EM centres in Stockholm and Copenhagen. Short research stays or secondments may also be arranged, depending on your
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, and/or ions or small molecules - such as drug candidates (i.e., "complexes") - enable or modulate the function of membrane proteins. The focus will be on studying such phenomena in ion channels
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methodological awareness and alignment with the project’s broader objectives. Application Components A complete application consists of: Cover Page (max. 1 page): A short motivation outlining your interest in
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structural investigations of co-aggregates of amyloid proteins and chaperones or of proteins with lipid membranes. DESCRIPTION OF PROJECT The project is focused i) on a class of chaperones that through
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researchers. Particular emphasis will be placed on research skills within the subject. For appointments to a post-doctoral position, the following shall form the assessment criteria: ability to develop and