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datasets for single nucleotide variants, structural variants, and tandem repeats relevant to FTLD Use cutting-edge bioinformatics software and methods, or develop novel tools when appropriate
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method, can engineer thousands of defined mutations in parallel in a single test tube in yeast. Strains are tagged by DNA barcodes, allowing to efficiently track mutations in cell populations during
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neuron electrophysiology as well as complex network dynamics in the context of specific perturbations. You will use these data to map the disease in terms of electrophysiological dynamics and stratify
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computational and machine learning approaches, you will decipher genomic regulatory programs and infer the evolutionary patterns of gene regulatory networks in cortical neurons, study their developmental origin