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Field
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Current modelling and simulations require either generic assumptions to be made for fluid dynamic based modelling leading to inaccuracies between modelled and experimental data or, intense
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) techniques and develop advanced cancer models including organoids and patient-derived xenografts from primary human tissue. Current projects include investigating extrachromosomal DNA (ecDNA), copy number and
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limitations in both measurement and modelling techniques. Current in-process measurement methods are restricted to surface-only monitoring devices (e.g., cameras and pyrometers), which fail to capture
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. The within-host model will be linked to: a clinical trial simulation, an essential tool in drug development, to inform the clinical trial design of novel treatments, an individual-based transmission model
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limited by radiation-induced liver fibrosis (RILF). Using a mouse model of HCC on fatty liver, the project will investigate how radiotherapy impacts tumour growth and liver fibrosis and test antifibrotic
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), the third leading cause of cancer deaths, often arising from fatty liver disease. While IGRT shows promise in treating HCC, its use is limited by radiation-induced liver fibrosis (RILF). Using a mouse model
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treatment processes through advanced machine learning, validated against physics-based models and experimental data. 2. System Integration: Integrating the DTs into material and energy balance equations
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for the collection of data to develop and validate prognostic models for filter degradation. Integrated Drive Generator (IDG) Rig: Simulates the operation of an aircraft's IDG, used to investigate fault detection
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for analysing complex materials, structures and model validation. The DIC community has developed guidelines to ensure robust measurements, continually advancing standards through ongoing challenges. In
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water basins across HMA. We will simulate future changes in temperature, precipitation, and snowmelt using climate projection models. These projections, combined with hydrological modelling, will allow us