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enzyme 1 (IRE1), the most evolutionary conserved UPR transducer, is an ER-resident transmembrane protein with a cytosolic dual kinase/RNase activity controlling pro-survival or pro-death signals. Yet
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of the new d-DNP setting, and develop solutions to improve its reproducibility or to correct the effect of irreproducibility on the NMR signal; ii) evaluate the performance of the experimental setting
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