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About the Project A fully funded PhD scholarship is available at UCL Electronic & Electrical Engineering (4 years, home tuition fees covered, stipend provided). Exceptional international candidates
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language model (LLM)-based genome design tools with bioprocess engineering to create next-generation therapeutic conjugative plasmids. These engineered plasmids will be optimised for industrial-scale
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Supervisors: Prof Manish Tiwari Prof Shervanthi Homer-Vanniasinkam Clinical Partner: The Royal National Orthopaedic Hospital (RNOH) Collaborator: Dr. Priya Mandal – UCL Mechanical Engineering
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). Design and fabricate patterned surfaces optimised for enzyme immobilisation. Assess synergistic antibiofilm efficacy under static and dynamic (flow-based) biofilm models. Apply advanced microscopy, protein
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-penetrating capabilities Evaluate delivery efficiency in cell-based models mimicking lung and immune tissues Identify structure–function relationships to inform rational design of future mucosal delivery
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mechanisms to guide the design and formulation of nanoparticles with superior drug delivery properties. Investigate the interaction between ultrasound, nanoparticles, and biofilms to assess antimicrobial
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guidelines for the design of improved organic materials. Interested candidates may want to take a look at our recent work: https://www.nature.com/articles/s41467-022-30308-5 & https://www.science.org/doi
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. Synthetic analogues will be developed and screened alone and in combination with existing antimicrobials. The ultimate goal is to design novel chemotherapeutic combinations that disrupt cell wall remodelling
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significantly reduce inappropriate antibiotic use, support NHS diagnostic capacity, and enhance AMR surveillance in community settings. The platform’s low-cost, power-free design makes it particularly suitable
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rather than the structured biofilms found in real-world environments. This project investigates how engineered surface topographies influence HGT dynamics, aiming to develop design principles for materials